For my Harley-Davidsons it's a completely different problem. I can imagine it's the same for chain drive bikes, but I haven't owned one in a long time. Getting the wheel into place and the axle through is fairly easy, as a rear wheel without a gear drive attached is much lighter. But then the fun starts, getting the proper chain or belt tension and the rear wheel and axle aligned so the bike tracks properly.
What a PITA! Being cheap, I originally didn't buy an alignment tool-how hard could this be? Really hard, so I broke down and bought a simple tool.
Best $16 I've spent on a bike ever! Get the tension you need, use the tool to mark the distance on that side of the bike (yes, Harley Sportsters but the belt on the "other side"!), go to the opposite side, slide axle into alignment, tighten everything, check again, torque everything and go for a "test ride"!
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